Goto Tsujo Mitsutoshi was the third son of Sennjo Mitsuharu of the Goto Taroemon house, and a grandson of Kenjo, the seventh head of the mainline Goto house. Because Mitsuyoshi, the biological heir and eldest son of the tenth head Renjo, died young of illness, Mitsutoshi married Renjo's daughter and was adopted into the main line. In Genroku 10 (1697), upon Renjo's retirement, he succeeded as the eleventh head of the Goto soke. Born in 4 (1664) with the childhood name Mitsuo and the common name Gennojo, he took Buddhist vows in Kyoho 5 (1720) and adopted the art name Tsujo, but fell ill and died on the twenty-seventh day of the twelfth month of the following year. For this reason, works bearing the Tsujo signature are limited to the final one year and eight months of his life, and surviving examples are extremely few, lending such pieces particular value as documentary material.
During Renjo's tenure the Goto mainline relocated from Kyoto to and settled there permanently. In Mitsutoshi's generation, responding to the Genroku cultural milieu, the house absorbed the rising influence of (town-carver workmanship), which was then gaining prominence. While maintaining the inherited traditions of iebori (the hereditary house style), Mitsutoshi incorporated fresh elements to meet contemporary taste, adding a new flavor atop established Goto standards. His chisel handling is characterized by broad, unhurried strokes possessed of a dignified tone, and the raised work is robustly built up with ample volume. His preferred materials are grounds with gold and silver , and he made liberal use of ' (gold-backed) reverse finishing and, on occasion, sokin (solid gold) construction of notable sumptuousness. Among his technical innovations, the left-right spreading compositional arrangement seen in his is said to have been first attempted by him, and he introduced novel surface treatments such as a nunome-like variant of texturing on rock elements. His are characteristically thick-backed and convey a notable sense of weight owing to the generous use of gold.
Mitsutoshi's significance within the Goto lineage lies in his role as the pivotal figure who bridged the formal tradition of the house with the expressive spirit of the Genroku era. From his generation onward the Goto family began to produce sword fittings more proactively, including , which had appeared only sparingly since the time of the fifth head Tokujo. He also served as authenticator and assembler of works by the celebrated Upper Three Generations — the founder Yujo, the second head Sojo, and the third head Joshin — issuing that remain important documents of connoisseurship. His favored subjects include the Goto house specialties of (sprays of chrysanthemum) and hai-ryu (crawling dragon) alongside more inventive themes such as rusu moyo (absent-figure designs) evoking the Seven Lucky Gods, Edomae marine motifs, and narratives drawn from the Nijushi-ko (Twenty-four Filial Exemplars). Whether working in the restrained idiom of traditional Goto okimono subjects or in compositions that breathe the urbane refinement of the townspeople, his pieces achieve a refreshing effect while clearly demonstrating the elevated dignity of the Goto house.